The Effect of Acute Xerostomia on Vocal Function

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To evaluate whether xerostomia can affect vocal function in an experimental model.


Randomized controlled study.


Academic center.


Twenty healthy young men.


Glycopyrrolate was administered to induce acute xerostomia in 10 men, and saline was administered to 10 men who served as controls.

Main Outcome Measures

Whole salivary flow rate and dry mouth scale were time-serially measured, and subjective and objective vocal functions were checked before and after treatment. The salivary and vocal functions were compared between groups.


Significant salivary hypofunction and symptoms developed within 90 minutes after the administration of glycopyrrolate. Vocal effort and phonation threshold pressure significantly increased (P<.005) and voice range profiles decreased in the xerostomia group (P = .003) but not in the control group. Other voice parameters were comparable between groups (P>.05). High correlations were also found between salivary and vocal parameters.


Our findings suggest that vocal function can be affected by xerostomia.

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