Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus1


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Abstract

AimTo investigate the effect of jujuboside A (JuA) on modulating gene expression in the hippocampus.MethodsThe spontaneous activity of mice was monitored, and the differential display polymerase chain reaction was adapted to screen differentially-expressed genes modulated by JuA in the mouse hippocampus.ResultsJuA significantly decreased the total activity intensity (P<0.01 vs control) at a dosage of 80 mg/kg, and the genes MAP/microtubule affinity-regulating kinase3 (Mark3) and retinitis pigmentosa GTPase regulator interacting protein 1 (Rpgrip1) were upregulated by JuA in the mouse hippocampus.ConclusionJuA had an inhibitory effect on the spontaneous activity of the mice, and JuA regulated the transcription of Mark3 and Rpgrip1 in the mouse hippocampus.

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