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The aim of this study was to determine which matrix metalloproteinases (MMPs) are involved with C-reactive protein (CRP) and which stage of rheumatoid arthritis (RA) correlated with MMP-9 or MMP-13 level.In the present clinical trial, we analysed MMP-9 activity and MMP-13 activity in 53 RA patients. We examined the presence of MMP-9 and MMP-13 in the synovium tissue and articular cartilage in RA patients by immunohistochemistry. In addition, we compared these factors and clinical Steinbrocker staging.We found that MMP-9 in blood serum correlates significantly with CRP. MMP-13 also correlates with CRP but the coefficiency with CRP is much higher in MMP-9 (r = 0.6694) than in MMP-13 (r = 0.4037). MMP-9 and MMP-13 did not correlated with rheumatoid factor (RF). MMP-9 level is increased in stages II and III in RA. On the other hand, MMP-13 is increased in stages III and IV. Our results indicated that early stage RA shows high MMP-9 release in serum while late stage RA shows high MMP-13 release.MMP-9 activity may correlate with synovium proliferation with vascularization, and serum MMP-13 activity may correlate with the grade of joint destruction in rheumatoid arthritis.