Extended indications for anti-tumor necrosis factor-α therapy

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Tumour necrosis factor-α is a pleiotropic cytokine which has a broad range of actions in inflammation, infection and immunity. TNF-α is supposed to play a crucial role in the pathogenesis of various autoimmune diseases. TNF-α blocking agents have been demonstrated to be highly effective in the treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and juvenile rheumatoid arthritis. TNF-α inhibitors also have been tried with other rheumatic diseases and have emerged as promising treatments. We here review the current evidences of effectiveness of the anti-TNF-α therapy in various autoimmune diseases.

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