Synthesis and structure-activity relationship studies of substituted isoquinoline analogs as antitumor agent

    loading  Checking for direct PDF access through Ovid


A number of substituted isoquinolin-1-ones, possible bioisosteres of the 5-aryl substituted 2,3-dihydroimidaz[2,1- a]isoquinolines, were synthesized and tested for their antitumor activity against five different human tumor cell lines. O-(3-hydroxypropyl) substituted compound (15) exhibited the best antitumor activity which is 3-5 times better than 5-[4′-(piperidinomethyl) phenyl]-2,3-dihydroimidazo[2,1- a]isoquinoline (1).

Related Topics

    loading  Loading Related Articles