Immunomodulatory Properties of 2-C-Methyl-D-Erythritol-2,4-Cyclopyrophosphate and the Search for Its New Derivatives

    loading  Checking for direct PDF access through Ovid


A strong immunomodulatory effect of 2-C-Methyl-D-erythritol-2,4-cyclopyrophosphate (MEC) responsible for the survival of bacteria was shown on isolated macrophages and in experimental infections in mice (typhoid and tularemia). Derivatives of MEC were found by 1H-NMR spectroscopy under stress conditions in colorless mutants of the bacteria and isolated to be subsequently purified and used for modulation of the immune system of animals.

    loading  Loading Related Articles