Immunomodulatory Properties of 2-C-Methyl-D-Erythritol-2,4-Cyclopyrophosphate and the Search for Its New Derivatives


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Abstract

A strong immunomodulatory effect of 2-C-Methyl-D-erythritol-2,4-cyclopyrophosphate (MEC) responsible for the survival of bacteria was shown on isolated macrophages and in experimental infections in mice (typhoid and tularemia). Derivatives of MEC were found by 1H-NMR spectroscopy under stress conditions in colorless mutants of the bacteria and isolated to be subsequently purified and used for modulation of the immune system of animals.

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