Obtaining of a High-Density Culture of Nocardioides sp.


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Abstract

Selection of carbon sources demonstrated ethanol to be the best substrate for a high-density Nocardioides sp. culture. A strategy for control over high-density fed-batch culture production was developed, which permitted maximizing the yield of biomass (21 g/l). The control, based on the ExpoDense algorithm, should be predetermined at the first phase and adaptive in the second phase of the two-phase process of high-density culture production.

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