Osteocalcin, growth, and inhaled corticosteroids: a prospective study

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ObjectivesTo determine the relationship between biochemical markers of bone metabolism and statural growth, and their suitability as surrogate markers of inhaled corticosteroid induced growth suppression.DesignRandomised, double blind, placebo controlled comparison of inhaled beclomethasone dipropionate 200 micro gram twice daily as dry powder for six months.SettingSouthampton.Outcome measuresSerum osteocalcin, urinary deoxypyridinoline, and statural growth.Subjects7 to 9 year old children with recurrent wheeze.ResultsThere were no significant differences in serum osteocalcin between the beclomethasone dipropionate and placebo group measured at baseline or after three and six months' treatment, while deoxypyridinoline was significantly higher in the placebo treated children after three months. Growth was significantly decreased in the beclomethasone dipropionate group over the course of the study. Growth over the six months, both in those receiving beclomethasone dipropionate and those receiving placebo, was significantly correlated with serum osteocalcin measured at three months and six months.ConclusionAlthough serum osteocalcin shows excellent correlation with growth, it is a poor marker for decreased growth associated with use of inhaled corticosteroids.(Arch Dis Child 1996;74:497-501)

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