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A cross-sectional study was conducted to evaluate nonoccupational biological exposure to 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) compounds and to identify the main factors associated with such exposure in a malaria endemic region in Mexico. Capillary gas column chromatography was used to determine levels of p,p′-DDT and its metabolites in plasma. The mean age of the 144 male participants was 28 yr. Mean p,p′-DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene) and p,p′-DDT levels were 203.5 μg/l and 67.4 μg/l, respectively. Those whose houses had been sprayed for malaria control had much higher p,p′-DDE levels (p < 0.001). High levels of chlorinated pesticides were found despite being banned in Mexico for agricultural and public health use. Findings demonstrate the role of antimalarial campaigns as a major contributing factor for high DDT plasma levels.