Correlations between interscapular deep temperature and plasma free fatty acid levels in pregnant women with hyperemesis gravidarum

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Objectives:The aim of the present study was to investigate whether deep temperature directly reflects underlying pathology in pregnant women with hyperemesis gravidarum.Subjects:We studied 24 women at first trimester hospitalized for hyperemesis gravidarum who had lost a mean of 4.3 kg since becoming pregnant and 20 pregnant controls who did not experience hyperemesis gravidarum and were matched for weeks of gestation and pre-conception weight and height.Methods:Serum free T3, T4, and plasma free fatty acid levels were determined, and deep temperatures of the interscapular tissues were measured. Measurements were compared at admission and after symptoms improved.Results:Free fatty acid, free T3, and T4 levels at admission were appreciably higher in the hyperemesis gravidarum group than in the control group (p<0.05). After symptoms improved, free fatty acid levels in patients had decreased by 29% and free T4 levels by 28% (p<0.05). A significant relationship was observed between reductions in free fatty acid level accompanying improvement in patient status and decreases in both free T3 and free T4 levels (p<0.05). Interscapular deep temperatures at admission (36.4 ± 0.5 C°) significantly decreased to 35.8 ± 0.9 C° after symptoms improved (p<0.05). Reductions in interscapular temperature as a result of improvements in patient status were significantly correlated with reductions in free fatty acid level (p<0.001).Conclusions:Deep temperatures of the interscapular region in hyperemesis gravidarum change in association with lipolysis as a result of transient hyperthyroidism. This phenomenon can be used as an indicator for evaluating improvements in the pathologic features of hyperemesis gravidarum.

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