02.43 Role of anti-peptide citrullinated antibodies in cardiovascular disease in rheumatoid arthritis

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Abstract

Background

Rheumatoid arthritis (RA) is a systemic autoimmune disease of unknown and multifactorial aetiology, whose prevalence is around 1% of the adult population. It most commonly affects women between the 4th and 6th decade. Patients with RA have an increased cardiovascular morbidity and mortality (CV) being the main cause of death. “Systematic Coronary Risk Evaluation” (SCORE) allows us to estimate the risk of death from cardiovascular disease as 10 years.

Objectives

To evaluate whether the presence of anti-peptide citrullinated (ACPA) antibodies is associated with increased frequency of cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA) or with greater SCORE.

Methods

observational, analytical case-control study nested in a cohort of patients diagnosed with AR follow-up in the Valme hospital area. Cases were considered the patients who have developed a myocardial infarction or cerebrovascular or ischaemic heart disease and controls RA patients without CVD. They all determined ACPA levels, the classic cardiovascular

Results

A total of 260 patients were included from a database of 327 patients with AR. In 67 of these, we coudn’t get the main variables of the sutdy, and were excluded.

Conclusions

In our sample, unlike other published studies, we found no differences in the occurrence of cardiovascular events, or the SCORE in patients ACPA (+) v ACPA (-). While subgroups of patients with ACPA + have a greater tendency to be treated with biological therapy. This lack of differences could also be explained by the early implantation of both primary and secondary prevention of cardiovascular disease in patients with RA.

References

Results from systematic screening for cardiovascular risk in outpatients with rheumatoid arthritis in accordance with the EULAR recommendations; ARD Online First, published on July 12, 2013 as 10.1136/annrheumdis-2013-20368

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