AB1233-HPR Cognitive complaints in patients with active systemic lupus erythematosus and past neuropsychiatric symptoms

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ObjectivesCognitive complaints are common in patients with systemic lupus erythematosus (SLE). Their association with disease and non-disease related factors have been inconsistently reported. We studied their relation to disease related factors including disease activity, neuropsychiatric history and non-disease related factors such as anxiety or depression.MethodsWe used cognitive symptoms inventory (CSI) for measuring cognitive impairment at 3 time-points 12 months apart/2015–2016/ and Hospital Anxiety and Depression Scale (HADS)-HADS-A and D.Disease activity was measured by SLEDAI.Results93 SLE patients were recruited at baseline (T0). Among them 59 had first re-evaluation (T1) and 34 had second re-evaluation (T2) at 12-month interval. Majority (72%, 24/34) of patients had stable CSI whereas 5.5% (2/34) of patients worsened CSI over 12 months. At T0, multivariate analysis revealed that higher CSI was associated with history of NPSLE (p=0.005) and psychiatric disease (p=0.04), higher HADS-A (p<0.001) and HADS-D (p<0.001) scores. CSI of active patients (SLEDAI>6) was not different from inactive patients. It did not change despite regression of disease activity in 12 months. There was no difference in CSI between T0 and T1 regardless of history of NPSLE, change in anxiety and depression at T1 (HADS-D>11 as cutoff).Multivariate linear regression analysis revealed change in HADS-A as the only significant predictive factor of change in CSI over time (β=0.774, 95% CI 0.43 – 1.12, p<0.001).Conclusions11.5% of SLE patients reported persistent cognitive symptoms.CSI had worsened in patients with NPSLE and psychiatric illness, anxiety or depression.Disclosure of InterestNone declared

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