AB1246-HPR Intra articular ozone or hyaluronic acid injection: which one is superior in patients with knee osteoarthritis? a 6-month randomized clinical trial

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Abstract

Background

Knee osteoarthritis (OA) is a common disease with great burden through pain and decreased function (1). Except for knee replacement surgery as a definite treatment (2), there are many other therapeutic modalities including non-pharmacologic choices and some heterogeneous drugs like oral, topical and intra articular ones (3). Recent studies have showed promising results of ozone application in OA (2,4–5).

Objectives

The aim of this study was to compare the effects of ozone therapy versus hyaluronic acid (HA) intra articular injection in patients with knee OA.

Methods

This prospective RCT studied 174 patients in two random groups: ozone and HA. We performed three weekly injections of Hyalgan® versus 10 ml of ozone solution in moderate knee OA patients. Participants were primarily evaluated and 6 months after injection using pain, stiffness and function questionnaires.

Results

No major adverse events were noted in the study. Total WOMAC score decreased in the ozone group from 40.8±9.8 to 20.4±4.9 (p<0.05) and in the HA group from 38.5±7.9 to 17.1±4.2 (p<0.05). A similar trend was observed in pain improvement according to VAS (table 1). Pain, stiffness and function significantly improved in both groups but no differences were found between groups.

Conclusions

Although both ozone and HA can be effectively used for improving function and reducing pain in selected patients with knee OA, neither of the two showed no superiority at 6 months follow up.

Disclosure of Interest

S. A. Raeissadat Shareholder of: None, Grant/research support from: None, Consultant for: None, Employee of: None, Paid instructor for: None, Speakers bureau: None, S. M. Rayegani Shareholder of: None, Grant/research support from: None, Consultant for: None, Employee of: None, Paid instructor for: None, Speakers bureau: None, M. Moridnia Shareholder of: None, Grant/research support from: None, Consultant for: None, Employee of: None, Paid instructor for: None, Speakers bureau: None, S. Rahimi Dehgolan Shareholder of: None, Grant/research support from: None, Consultant for: None, Employee of: None, Paid instructor for: None, Speakers bureau: None

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