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The effects of etidocaine HCl and of tetracaine HCl on the spinal cord and spinal roots of rabbits were evaluated after intrathecal administration. Etidocaine at 0.5, 1, and 2 percent produced no adverse effects on the cord and spinal roots. The cord of one out of four of the animals that received 4 percent etidocaine showed microscopic lesions that could be attributed to the drug. Tetracaine HCl at 2 percent produced abnormalities that could be attributed to the drug in two out of four animals so treated. No effects attributable to the drug were noted at 0.25, 0.5, and 1 percent tetracaine.