Morphologic Effects of Intrathecal Etidocaine and Tetracaine on the Rabbit Spinal Cord

    loading  Checking for direct PDF access through Ovid


The effects of etidocaine HCl and of tetracaine HCl on the spinal cord and spinal roots of rabbits were evaluated after intrathecal administration. Etidocaine at 0.5, 1, and 2 percent produced no adverse effects on the cord and spinal roots. The cord of one out of four of the animals that received 4 percent etidocaine showed microscopic lesions that could be attributed to the drug. Tetracaine HCl at 2 percent produced abnormalities that could be attributed to the drug in two out of four animals so treated. No effects attributable to the drug were noted at 0.25, 0.5, and 1 percent tetracaine.

    loading  Loading Related Articles