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For some scheduled cases, there may be no previous cases of the same procedure type by the same surgeon for use in estimating the duration of the new case. We evaluated which of 16 different methods of analysis of other surgeons' cases of the same procedure type resulted in the most accurate prediction of the duration of the case that the surgeon had not recently scheduled. We analyzed durations for 4,955 cases, from an operating room information system, for which a surgeon had only scheduled the procedure once, and for which other surgeons had scheduled that same procedure one or more times. Using these data, we determined the difference between the actual duration of the new case and the estimated duration of the new case as calculated by each of the methods (average absolute error of 1.1 h with average case duration of 3.1 h).When no recent historical time data are available for a surgeon doing a given procedure, the mean of the durations of cases of the same scheduled procedure performed by other surgeons is as accurate an estimate as more sophisticated analyses. More research is needed to improve the precision of estimates of case durations.