Anesthesia & Analgesia. 110(6):1636–1643, JUNE 2010
DOI: 10.1213/ANE.0b013e3181de0ab6
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PMID: 20435944
Issn Print: 0003-2999
Publication Date: June 2010
The Role of the Perioperative Period in Recurrence After Cancer Surgery
Antje Gottschalk;Sonal Sharma;Justin Ford;Marcel Durieux;Mohamed Tiouririne;
+ Author Information
From the *Department of Anesthesia, University of Virginia, Charlottesville, Virginia; and †Department of Anesthesiology and Intensive Care Medicine, University Muenster, Muenster, Germany.
Abstract
A wealth of basic science data supports the hypothesis that the surgical stress response increases the likelihood of cancer dissemination and metastasis during and after cancer surgery. Anesthetic management of the cancer patient, therefore, could potentially influence long-term outcome. Preclinical data suggest that beneficial approaches might include selection of induction drugs such as propofol, minimizing the use of volatile anesthetics, and coadministration of cyclooxygenase antagonists with systemic opioids. Retrospective clinical trials suggest that the addition of regional anesthesia might decrease recurrence after cancer surgery. Other factors such as blood transfusion, temperature regulation, and statin administration may also affect long-term outcome.
