Anesthesiology. 83(6):1293–1301, DECEMBER 1995

PMID: 8533922

Issn Print: 0003-3022

Publication Date: December 1995


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Quaternary Ammonium Derivative of Lidocaine as a Long-acting Local Anesthetic

G. Wang;C. Quan;M. Vladimirov;W. Mok;J. Thalhammer;

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Abstract

BackgroundUse of long-acting local anesthetics that elicit complete neural blockade for more than 3 h often is desirable in pain management. Unfortunately, clinically available local anesthetics are in general not suitable for prolonged analgesia. This report describes the organic synthesis and functional testing of a lidocaine derivative that appears to fulfill the criteria of long-acting local anesthetics.

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