AIDS. 14(13):1985-1991, SEPTEMBER 8TH, 2000

PMID: 10997404

Issn Print: 0269-9370

Publication Date: September 8th, 2000


Share this on facebook   Share this on Twitter   Share this on LinkedIn   Email this article  



Print

Impact of combination antiretroviral therapy on the risk of tuberculosis among persons with HIV infection

Enrico Girardi;Giorgio Antonucci;Paola Vanacore;Marco Libanore;Isabella Errante;Alberto Matteelli;Giuseppe Ippolito;

+ Author Information


    loading  Checking for direct PDF access through Ovid

Abstract

ObjectiveTo assess the association between use of different antiretroviral regimens and incidence of tuberculosis among HIV-infected individuals.DesignObservational, multicenter, prospective cohort study.Setting and patientsTwenty-eight infectious diseases hospital units in Italy. A total of 2160 HIV-infected persons were considered for enrolment in a study on the implementation of tuberculosis preventive therapy between 1 May 1995 and 30 April 1996. The 1360 subjects who completed tuberculin screening at base-line were included in this analysis. Information on the use of antiretroviral therapies over time was collected. The median duration of follow-up was 104 weeks and 997 subjects (73.3%) completed the study.Main outcome measureIncidence of active tuberculosis according to different types of antiretroviral therapy.ResultsEighteen cases of tuberculosis were observed with an overall incidence rate of 0.79 per 100 person–years of observation [95% confidence interval (CI), 0.51–1.31]. Tuberculin positivity and low CD4+ lymphocyte count were the only base-line variables independently associated with the risk of tuberculosis. During follow-up, 637 patients took double combination antiretroviral therapy and 387 took triple combination therapy. After adjusting for base-line characteristics of enrolled individuals, the relative hazard of tuberculosis was 0.16 (95% CI, 0.03–0.74) for double combination therapy and 0.08 (95% CI, 0.01–0.88) for triple combination therapy compared with no therapy or monotherapy.ConclusionsCombination antiretroviral therapy significantly reduced the risk of tuberculosis in HIV-infected persons. In industrialized countries, the widespread use of this treatment may determine a decrease in the incidence of HIV-associated tuberculosis, possibly contributing to a reduction in the overall incidence of tuberculosis.

Related Topics

    Related Articles

        loading  Loading Related Articles