The diagnostic utility of autoantibodies in adult and juvenile myositis

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Purpose of reviewThe purpose of this study is to review recent advances in the diagnostic utility of autoantibodies in dermatomyositis.Recent findingsAlternative nonspecialist testing methods have been developed for anti-transcription intermediary factor 1 gamma, anti-MDA5 and anti-nuclear matrix protein 2, which are potentially exploitable by any hospital laboratory. Although these have yet to be validated for diagnostic use, it is likely that testing for myositis-specific antibodies will soon become readily available.SummaryThe identification of myositis-specific autoantibodies provides both diagnostic and prognostic information and offers a unique opportunity to adopt a stratified approach to treatment. Their identification, in many cases, should prevent the need for invasive diagnostic tests such as muscle biopsy.

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