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We sought to evaluate the efficacy of a limited training dedicated to residents without knowledge in ultrasound for performing goal-oriented echocardiography in ICU patients.Prospective pilot observational study.Medical-surgical ICU of a teaching hospital.61 consecutive adult ICU patients (SAPS II score: 38 ± 17; 46 ventilated patients) requiring a transthoracic echocardiography were studied.After a curriculum including a 3-h training course and 5 h of hands-on training, one of four noncardiologist residents and an intensivist experienced in ultrasound subsequently performed hand-held echocardiography (HHE), independently and in random order. Assessable “rule in, rule out” clinical questions were purposely limited to easily identifiable conditions by the sole use of two-dimensional imaging.When compared with residents, the experienced intensivist performed shorter examinations (4 ± 1 vs. 11 ± 4 min: p < 0.0001) and had significantly less unsolved clinical questions [3 (0.8%) vs. 27 (7.4%) of 366 clinical questions: p < 0.0001]. When addressed, clinical questions were adequately appraised by residents: left ventricular systolic dysfunction [Kappa: 0.76 ± 0.09 (95% CI: 0.59–0.93)], left ventricular dilatation [Kappa: 0.66 ± 0.12 (95% CI: 0.43–0.90)], right ventricular dilatation [Kappa: 0.71 ± 0.12 (95% CI: 0.46–0.95)], pericardial effusion [Kappa: 0.68 ± 0.18 (95 CI: 0.33–1.03)], and pleural effusion [Kappa: 0.71 ± 0.09 (95% CI: 0.53–0.88)]. The only case of tamponade was accurately diagnosed by the resident.Limited training of noncardiologist ICU residents without previous knowledge in ultrasound appears feasible and efficient to address simple clinical questions using point-of-care echography. Influence of the learning curve on diagnostic accuracy and potential therapeutic impact remain to be determined.