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Documentation of treatment effects in acutely sick frail older patients in geriatric evaluation and management units (GEMUs) is scarce. The present study evaluated whether treatment in a GEMU would reduce mortality as compared to traditional treatment delivered in the Department of Internal Medicine.Prospective randomized trial.GEMU or general medical wardAcutely sick frail patients aged 75 and older who had been admitted to the Department of Internal Medicine were randomly assigned to treatment in the GEMU (n = 127) or to the general medical wards (n = 127). The following inclusion criteria were used to target frail patients: chronic disability, acute impairment of single activity of daily living, mild/moderate dementia, confusion, depression, imbalance/dizziness, falls, impaired mobility, urinary incontinence, malnutrition, polypharmacy, vision or hearing impairment, social problems, or prolonged bedrest.In the GEMU, the treatment strategy emphasized interdisciplinary assessment of all relevant disorders, prevention of complications and iatrogenic conditions, early mobilization/rehabilitation, and comprehensive discharge planning. The control group received treatment as usual from the Department of Internal Medicine. After discharge neither group received specific follow-up.Mortality and causes of death.Mortality in the intervention and control groups, respectively, was 12% and 27% at 3 months (P = .004), 16% and 29% (P = .02) at 6 months, and 28% and 34% (P = .06) at 12 months. The hazard ratio was 0.39 (95% confidence interval = 0.21–0.72) at 3 months. The main cause of death was cardiovascular disease.Treatment of acutely sick, frail, older patients in a GEMU substantially reduced mortality.