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1. Intracerebral or intratheeal administration of alum phosphate in rabbits resulted in the development of convulsive seizures, as well as of characteristic neuronal changes throughout the CNS.2. The neuronal change consisted in a hydropic alteration of the cytoplasm and in a conspicuous neurofibrillary degeneration.3. Chemical analysis of brain obtained from animals sacrificed during the terminal convulsive state demonstrated significant decreases in brain water and chloride space, and a relatively large increase in the thiocyanate space.4. The effect of alum phosphate which is described may provide an experimental model for further investigations of the morphological substrate of epileptic neuronal activity, as well as of the pathomechanism of neurofibrillary degeneration.