EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION: 2. ELECTRON MICROSCOPY, PHOSPHATASE HISTOCHEMISTRY AND ELECTRON PROSE ANALYSIS


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Abstract

SUMMARY1. Electron microscopy has demonstrated the fibrillar content of the neuronal lesions in rabbits treated with alum phosphate.2. The filaments involved in these Alzheimer-like tangles are less than 150 Å wide, have side branches, and are perhaps tubular. They are similar to the filaments found in the human disease.3. Traces of aluminum were found in the affected rabbit neurons by the Philips Electron Probe Analyzer. Neither aluminum nor other elements were found by similar analysis of human neurofibrillary tangles.4. The alum-induced tangles are contrasted with the lesions in distended axons of rats treated with imidodiproprionitrile.

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