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LUCÍA, A., J. HOYOS, M. PÉREZ, A. SANTALLA, and J. L. CHICHARRO. Inverse relationship between V̇O2max and economy/efficiency in world-class cyclists. Med. Sci. Sports Exerc., Vol. 34, No. 12, pp. 2079–2084, 2002.To determine the relationship that exists between V̇O2max and cycling economy/efficiency during intense, submaximal exercise in world-class road professional cyclists.Each of 11 male cyclists (26 ± 1 yr (mean ± SEM); V̇O2max: 72.0 ± 1.8 mL·kg−1·min−1) performed: 1) a ramp test for V̇O2max determination and 2) a constant-load test of 20-min duration at the power output eliciting 80% of subjects’ V̇O2max during the previous ramp test (mean power output of 385 ± 7 W). Cycling economy (CE) and gross mechanical efficiency (GE) were calculated during the constant-load tests.CE and GE averaged 85.2 ± 2.3 W·L−1·min−1 and 24.5 ± 0.7%, respectively. An inverse, significant correlation was found between 1) V̇O2max (mL·kg−0.32·min−1) and both CE (r = −0.71;P = 0.01) and GE (−0.72;P = 0.01), and 2) V̇O2max (mL·kg−1·min−1) and both CE (r = −0.65;P = 0.03) and GE (−0.64;P = 0.03).A high CE/GE seems to compensate for a relatively low V̇O2max in professional cyclists.