aDepartment of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, PA, USAbSchool of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA, USAcDepartment of Neurology, Drexel University College of Medicine, Philadelphia, PA, USAdDepartment of Cancer Biology, Thomas Jefferson University, Cancer Genomics Laboratory, Kimmel Cancer Center, Philadelphia, PA, USAeJanssen Research and Development LLC, Spring House, PA, USAfDepartment of Molecular Medicine, Sapienza Universita di Roma, Rome, Italy