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Personal digital assistants (PDAs) have taken an increasing role in the practice of otolaryngology. PDAs provide an extension of the resources available on the user's PC. Handheld devices currently are being used for e-prescribing, charge capture, and accessing daily schedules and reference tools. Future applications may include education on medications, dictation, order entry, and test-results reporting. These applications of PDAs in the practice of otolaryngology will be reviewed.