Analysis of Interleukin-8, Interleukin-10, and Tumor Necrosis Factor-α in the Cerebrospinal Fluid of Patients With Cervical Spondylotic Myelopathy


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Abstract

Study DesignRetrospective cohort study.ObjectiveThe expression of interleukin-8 (IL-8), IL-10, and tumor necrosis factor-α (TNF-α) were measured in the cerebrospinal fluid (CSF) of patients with cervical myelopathy. The purpose of this study was to examine whether the CSF levels of those 3 cytokines differ significantly among 3 groups of patients with different diseases.MethodsIL-8, IL-10, and TNF-α levels were analyzed using enzyme-linked immune assay. CSF samples were collected from 3 groups of patients. The cervical spondylotic myelopathy (CSM) group consisted of 35 patients. The ossification of the posterior longitudinal ligament group [(OPLL) group] consisted of 7 patients, and the control group consisted of 12 patients. The concentration of IL-8 was 69.0±35.2 pg/mL in the CSM group, 82.1±46.7 pg/mL in the OPLL group, and 43.5±20.9 pg/mL in the control group. The concentration of IL-8 was significantly higher in the CSM and OPLL groups than in the control group (P<0.05). There was no significant difference between the CSM group and OPLL group. The concentration of IL-10 and TNF-α in all groups was below the sensitivity of the measurements.ConclusionsIn this study, the concentration of IL-8 was high in CSM and OPLL patients. However, the concentration of IL-10 and TNF-α was below the sensitivity of the measurements.

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