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After undergoing tonsillectomy and adenoidectomy (T&A), children may experience significant pain. Clonidine, an α2 agonist, exhibits significant analgesic properties. The current investigation sought to determine whether intramuscular (I.M.) clonidine would decrease pain in paediatric patients undergoing T&A.Thirty-nine children undergoing elective T&A were studied. Following inhalational anaesthetic induction, fentanyl (2 μg·kg−1) was given intravenously, acetaminophen (paracetamol) (30 mg·kg−1) was given rectally and the children then randomly received an i.m. injection of either normal saline or clonidine (2μg·kg−1). Perioperative analgesic requirements in the postanaesthesia care unit and at home following hospital discharge were evaluated.There were no significant demographic, analgesic consumption, haemodynamic or pain score differences between the groups.We do not recommend adding i.m. clonidine (2 μg·kg−1) to the analgesic regimen of children undergoing tonsillectomy and adenoidectomy.