Mortality and Cancer Experience of Quebec Aluminum Reduction Plant Workers. Part I: The Reduction Plants and Coal Tar Pitch Volatile (CTPV) Exposure Assessment

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Objectives:This paper presents the exposure assessment and job-exposure matrix (JEM) used to estimate coal tar pitch volatile (CTPV) exposure for a study of mortality and cancer incidence in aluminum smelter workers in Quebec, Canada.Methods:Historical CTPV exposure was assessed by estimating benzene-soluble material (BSM) and benzo[a]pyrene (B[a]P) levels for combinations of job and time period. Estimates were derived by using several procedures including averaging measurement data, a deterministic mathematical model using process-related correction factors, and expert-based extrapolation.Results:The JEM comprised 28,910 jobs, covering 7 facilities from 1916 to 1999. Estimated exposures ranged from 0.01 μg/m3 to 68.08 μg/m3 (B[a]P) and 0.01 mg/m3 to 3.64 mg/m3 (BSM) and were lowest before 1940 and after 1980.Conclusion:This methodology constitutes an improvement compared with methods used for previous studies of the Quebec cohort.

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