Job Strain and Incident Metabolic Syndrome Over 5 Years of Follow-Up: The Coronary Artery Risk Development in Young Adults Study

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Background:Theories of stress-induced metabolic syndrome predict that job strain would increase risk. Few studies have evaluated this association.Objective:To evaluate the association between job strain and the risk of metabolic syndrome.Methods:We investigated associations between job strain and incident metabolic syndrome adjusted for sociodemographic factors, health behaviors, and depressive symptoms over 5 years among 2966 black and white men and women in the Coronary Artery Risk Development in Young Adults study. Job strain was categorized by Karasek's model: high demands/low control; high demands/high control; low demands/low control; and low demands/high control.Results:Compared with persons in low-strain jobs, men in active jobs (adjusted hazards ratio, 2.7; 95% confidence interval, 1.5 to 4.9) and women in high strain jobs (adjusted hazards ratio, 2.2; 95% confidence interval, 1.0 to 4.6) had significantly increased risk of metabolic syndrome.Conclusion:Job strain may be a modifiable risk factor for metabolic syndrome and subsequent cardiovascular disease.

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