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Superficially metastatic melanoma still represents a challenging situation for oncologists and a distressing condition for patients. In this circumstance, local treatment by electrochemotherapy, that is, the combination of brief permeabilizing electric pulses with a low-toxicity anticancer drug, can be a valuable treatment option in selected patients who are ineligible/refractory to systemic treatments or require rapid palliation of symptomatic cutaneous disease. J. Surg. Oncol. 2014 109:301–307. © 2013 Wiley Periodicals, Inc.