Successful Treatment of a Critically Ill Patient with Disseminated Coccidioidomycosis, Using Adjunctive Interferon-γ

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Conventional antifungal therapy was not successful for a critically ill patient who had been hospitalized for 137 days in the intensive care unit with disseminated Coccidioides immitis infection and respiratory failure. The addition of interferon-γ to the therapeutic regimen resulted in improvement and discharge from the hospital. Adjunctive interferon-γ used in the successful treatment of severe coccidioidomycosis has not been reported previously.

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