The Journal of Infectious Diseases. 210(7):1042–1046, OCTOBER 01, 2014

DOI: 10.1093/infdis/jiu206

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PMID: 24688071

Issn Print: 0022-1899

Publication Date: October 01, 2014


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Tumor Necrosis Factor α Is Associated With Viral Control and Early Disease Progression in Patients With HIV Type 1 Infection

Sagar Vaidya;Christian Korner;Michael Sirignano;Molly Amero;Sue Bazner;Jenna Rychert;Todd Allen;Eric Rosenberg;Ronald Bosch;Marcus Altfeld;

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Abstract

Inflammation in early human immunodeficiency virus type 1 (HIV-1) disease progression is not well characterized. Ninety patients with untreated primary HIV-1 infection were studied to determine associations of inflammatory proteins with early disease progression. High plasma tumor necrosis factor α (TNF-α) levels (≥8.5 pg/mL) were significantly associated with an increased viral load set point and shorter times to reaching a CD4+ T-cell count of <500 cells/mm3 and initiating antiretroviral therapy. The increased risk of reaching a CD4+ T-cell count of <500 cells/mm3 in the group with high TNF-α levels was driven by viral load but was independent of concurrent CD4+ T-cell count. Thus, TNF-α appears to be an important mediator of inflammation in patients with poor viral control and early HIV-1 disease progression.

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