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Approaching almost 20 years of activity (and 10 years this year since the Joanna Briggs Institute, JBI, model of evidence-based healthcare was first published), the JBI remains one of the most successful international organizations to focus on the synthesis, transfer, and implementation of research evidence. Although similar in age and focus to the Cochrane Collaboration and other organizations of this nature, JBI has, from its inception, taken a broader view on what constitutes evidence to inform clinical decision making at the point of care and the need to be inclusive in order to answer the many different types of clinical and other care questions needing answers. The Institute published the JBI model of evidence-based healthcare 10 years ago this year, outlining a developmental framework of evidence-based practice that attempted to situate healthcare evidence and its role and use within the complexity of practice settings globally. Guidance on how to conduct reviews of different evidence types was limited at that time and has come a long way in the last decade. With a focus on both the scientific and pragmatic elements of the translational cycle, this article explores the history of methodological development of the Institute and postures where to from here.