The Polish ventricular assist device (Polvad) has been used successfully in clinical contexts for many years. The device contains two single-disc valves, one at the inlet and one at the outlet connector of the pneumatic pump. Unfortunately, in recent years, a problem has occurred with the availability of single-disc valves. This article presents the possibility of using bileaflet mechanical heart valve prostheses in the Polvad to avoid a discontinuity in clinical use. The study is based on experimental and numerical simulations and comparison of the distribution of flow, pressure, and stress (wall, shear, and turbulent) inside the Polvad chamber and the inlet/outlet connectors fitted with Sorin Monodisc and Sorin Bicarbon Fitline valves. The type and orientation of the inlet valve affects valve performance and flow distribution inside the chamber. Near-wall flow is observed for single-disc valves. In the case of bileaflet valves, the main jet is directed more centrally, with lower shear stress but higher turbulent stress in comparison with single-disc valves. For clinical usage, a 45° orientation of the bileaflet inlet valve was chosen, as this achieves good washing of the inlet area near the membrane paste surface. The Polvad with bileaflet valves has now been used successfully in our clinic for over a year and will continue to be used until new assist devices for heart support are developed.