Neonatal Anesthetic Pharmacology: A Review

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Anatomic and physiologic differences between neonates and adults1 influence the practice of pediatric anesthesia. Of equal importance may be differences in quantitative pharmacologic responses between adults and neonates to anesthetic agents and adjuncts. It is the object of this paper (1) to review evidence, based on the work of others, that the neonate's response to anesthetic agents and adjuncts differs from that of the adult and (2) to offer possible explanations for these differences. Since published observations concerning these drugs in neonates are somewhat limited, pertinent data based on animal experiments will also be discussed, in the hope of stimulating additional observations in human subjects.

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