Defect in Oxygenation Associated with Mannitol

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Mannitol is an osmotic diuretic used during intracranial surgical procedures to reduce brain size and thereby to improve operating conditions. It is distributed in the extracellular fluid and therefore can be accompanied by an acute expansion of extracellular fluid volume.1 This may have a detrimental effect on arterial oxygenation as illustrated by the following patients.

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