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Beta-2-microglobulin (β2M) associated amyloidosis has been seen in patients with chronic renal failure after long-term hemodialysis. However, the exact mechanism of β2M formation and accumulation is not clinically understood. In this investigation, the formation and removal kinetics of β2M were studied by compartmental modeling of a patient dialyzer system. Statistical and parametric analyses of model equations, coupled with clinical data from selected patients, enabled us to predict the behavior and influence of membrane materials upon the clearance characteristics of β2M during and between hemodialysis treatments.