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This article provides a systematic and critical review of all behavioral science research articles about Asian Americans published in 2010. As the second review of the series, we followed the methodology and format employed in the first annual review of Asian American psychology articles published in 2009 (B. S. K. Kim, Wong, & Maffini, 2010) to facilitate a discussion of trends in contents and methods of published research articles in the field. A search using PsycINFO identified 261 articles that were coded for topic areas, research methodology, and populations studied. We also provide a narrative summary of the articles, categorized thematically by topic areas, and conclude with a review of methodological and topical trends in empirical research of Asian Americans.