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Diabetes has been the fourth leading cause of death in Taiwan since 2002 and is one of the top four most prevalent chronic diseases worldwide. Patients who have diabetic foot, as well as their families, are faced with the burden of possible limb amputation. The aim of this study was to explore the amputation decision-making process with patients with diabetic foot and their families.Grounded theory was used in this study. Data from 16 participants at a regional hospital in Taiwan were collected using purposive sampling. The data analysis was conducted through open coding, axial coding, selective coding, and memo writing.The study revealed that the core factor in the decision-making process was “amputation in order to survive.” Patients and families additionally considered “the devastation of experiencing multiple diseases,” “treatment of poorly healing wounds,” and “facing the decision of whether to undergo amputation.”After understanding the patients’ decision-making process regarding amputation, healthcare providers should be encouraged to empathize with such patients. Further, providers should respect the patients’ and families’ decision and provide them with necessary care. Future research should explore professional perspective and family members’ care process for amputees to understand the decision-making process of patients who require amputation.