Vitamin E, LDL, and Endothelium: Brief Oral Vitamin Supplementation Prevents Oxidized LDL-Mediated Vascular Injury In Vitro

    loading  Checking for direct PDF access through Ovid

Abstract

In previously reported in vitro studies, we found that heme, a physiologically widespread hydrophobic iron compound, can rapidly generate oxidized low-density lipoprotein (LDL), which then becomes cytotoxic to cultured vascular endothelial cells; both LDL oxidation and endothelial cytotoxicity were inhibited by incubation with exogenous a-tocopherol (vitamin E) or ascorbic acid (vitamin C). Seeking relevance to in vivo conditions, we performed a study in which 10 human volunteers were given daily antioxidant supplements of 800 IU of DL-

Related Topics

    loading  Loading Related Articles