The Women's Health Initiative (WHI) included a Dietary Modification Trial with the primary endpoints looking at breast and colorectal cancer. More than 48,000 postmenopausal women were randomized into either a dietary intervention with a goal of 20% calories from fat with a high intake of vegetables, fruit, and grains, or a control group simply given nutrition information. At baseline, the women had a mean age of 62.3 years, mean body mass index of 29.1 kg/m2 (over-weight), and a dietary fat intake of at least 32% of total calories. This was not a weight-loss trial, but the monitoring of the two groups included measuring body weight. The intervention group lost a mean of 2.2 kg during the first year and maintained this weight over 7.5 years. The control group had modest weight gain between ages 50 and 70. Among the women in the intervention group, the lower the fat intake the greater the weight loss. A greater intake of vegetables and fruit also resulted in greater weight loss. Grain intake was neutral with respect to weight. The authors conclude that a low-fat predominately carbohydrate eating pattern does not result in weight gain in postmenopausal women.
Source:Howard BV, et al. Low-fat dietary pattern and weight change over 7 years: The Women's Health Initiative Dietary Modification Trial. JAMA 2006;295:39–49.HowardBVet alLowfat dietary pattern and weight change over 7 years: The Womens Health Initiative Dietary Modification Trial.JAMA200629539-49