Pre-Operative Intravenous Dexamethasone Prevents Auditory Threshold Shift in a Guinea Pig Model of Cochlear Implantation

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Aim:To protect hearing during cochlear implantation with systemic administration of dexamethasone.Methods:Seventeen normal-hearing guinea pigs were randomly allocated to receive an intravenous injection of either normal saline (control), low- (0.2 mg/kg) or high- (2 mg/kg) dose dexamethasone 60 min prior to cochlear implantation. Auditory brainstem response (ABR) threshold shifts (2–32 kHz) were estimated between pre- and 4-week-postoperative levels.Results:ABR threshold shifts (8–32 kHz) observed in control and low-dose steroid groups were significantly reduced in the high-dose steroid group.Conclusions:A single, high-dose injection of intravenous dexamethasone protected hearing during cochlear implantation.

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