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The prevention of postoperative infection complications in a patient with chronic idiopathic neutropenia treated with granulocyte colony stimulating factor (G-CSF) is reported. A 48-year-old woman who presented with chronic idiopathic neutropenia causing life-long recurrent infections, and postoperative suppurative wound infections, presented for elective coronary artery surgery. The patient was successfully treated with G-CSF, resulting in a significantly higher neutrophil count and no infection complications in the peri-operative period. Peri-operative G-CSF therapy in patients with chronic idiopathic neutropenia is effective in increasing the total neutrophil count, and decreasing infection complications.