Therapeutic Potential of Endocannabinoid-Hydrolysing Enzyme Inhibitors
Action of Celecoxib on Hepatic Metabolic Changes Induced by the Walker-256 Tumour in Rats
Protective Effects of Sasanquasaponin on Injury of Endothelial Cells Induced by Anoxia and Reoxygenation in vitro
Combination Therapy of Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-γ Ligand, and NMDA Receptor Antagonist (MK-801) on Experimental Embolic Stroke in Rats
Effect of Antipsychotics on Creatine Kinase Activity in Rat Brain
Effects of Marjoram Volatile Oil and Grape Seed Extract on Ethanol Toxicity in Male Rats
Comparison of Reactivating and Therapeutic Efficacy of Two Salts of the Oxime HI-6 against Tabun, Soman and Cyclosarin in Rats
Protection of Arsenic-Induced Hepatic Disorder by Arjunolic Acid
Pharmacokinetics of Two Randomized Trials Evaluating the Safety and Efficacy of Indinavir, Saquinavir and Lopinavir in Combination with Low-Dose Ritonavir
Ellagic Acid Prevents Cisplatin-Induced Oxidative Stress in Liver and Heart Tissue of Rats
The in vitro Inhibitory Potential of Trade Herbal Products on Human CYP2D6-Mediated Metabolism and the Influence of Ethanol
The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy
Harmonization of the work of the ethics committees in Germany
Pharmacotherapy with current oral antidiabetic drugs
Influence of nanostructured calcium-phosphate particles on rat osteosarcoma cells
New pharmacological principles in the therapy of type 2 diabetes mellitus
Opportunities for joint pharmacovigilance activities
Vaccination against human pathogen papilloma viruses
Role of intestinal uptake transporters for the pharmacokinetics of drugs
Inclusion of women in clinical trials
New aspects of cytochrome P450 research
Non-responder to psychiatric drug treatment
Evaluation of pediatric studies by the ethics committee
Initial experience with ertapenem in clinical practice
Specific aspects and challenges of clinical trials in children
Mapping translational research in personalized therapeutics
Randomized controlled trials as obligatory requirement of cost-effectiveness analysis? Study assessment by BfArM and IQWiG
European regulations for first-in-human clinical trials
Therapeutic improvement in lymphoblastic leukaemia therapy
New drug delivery systems
Drug-eluting stents in coronary artery disease
Limited significance of randomized controlled trials
Cancer immunotherapeutics
Role of membrane transporters in liver disease
Hepatic porphyrias
Hepatotoxicity in drug development
Therapy of chronic viral hepatitis
First administration of the novel selective dihydrofolate reductase inhibitor iclaprim in healthy male volunteers
Calcium balance during administration of calcium carbonate or sevelamer in individuals with normal renal function
Update on safety and antitumour effects of an oncolytic herpes simplex virus, NV1020, administered repeatedly via hepatic artery infusion prior to second-line chemotherapy, in patients with colorectal adenocarcinoma metastatic to the liver
Fentanyl produces higher vagal effects in comparison to sufentanil
Differential opioid action on sensory and affective cerebral pain processing assessed by functional magnetic resonance imaging
Aspirin and ibuprofen reduce nicotinic acid induced flushing
Voriconazole therapeutic drug monitoring
Correlation of near-infrared laser-induced tumour fluorescence intensities with the intratumoural structures quantified histologically by using stereological tools
Methylphenidate and sulpiride plasma concentrations as related to pharmacological functional magnetic resonance imaging in healthy male volunteers
Characterization of vascular reactivity after pioglitazone and candesartan treatment in healthy subjects
First results of a first-in-man proof of concept study of an anti-CD4mAb-fragment for the imaging of chronic inflammation in patients with active rheumatoid arthritis
Label versus off-label use for an antibiotic with clearly defined approval (indication) in Dresden, Saxony
The effects of venlafaxine on autonomic functions in healthy subjects
Haemodynamic changes induced by eating and long-lasting supine position in healthy men
Adjuvant vaccination after nephrectomy prolongs overall survival in patients with renal cell carcinoma
Hospital admissions due to adverse antibiotic reactions
Individualization of pharmacotherapy in old patients decreases the risk of adverse drug interactions occurrence
Optimization of pain pharmacotherapy in old patients
Effect of the dual pathway inhibitor cimetidine on the pharmacokinetics of roflumilast and its active N-oxide
Enterohepatic circulation of the THC-metabolite 11-nor-Δ9-carboxy-tetrahydrocannabinol (CTHC) after intravenous administration of CTHC in healthy human subjects
No effect of high-dose metronidazole on cytochrome P450 3A activity in a drug interaction study with the sensitive substrate budesonide
CYP3A4 phenotyping by plasma 4β-hydroxycholesterol?
Isolation and analytical assay development of 8-hydroxy-efavirenz for the quantification in plasma
Pharmacokinetics and metabolism of voriconazole in patients
Influence of ketoconazole on the pharmacokinetics and safety of intravenous iclaprim
Impact of long-term (14 days) efavirenz administration on CYP3A4 activity
Influence of concomitant administration of St. John's wort and ritonavir on CYP3A4 activity
Tissue penetration and pharmacokinetics of moxifloxacin at steady state in patients with diabetic foot infections
Posaconazole serum concentrations in patients before and after the day of stem cell transplantation
Disposition of sirolimus is not influenced by comedication of ezetimibe in healthy subjects
Metabolic disposition of flupirtin in man assessed by LC-MS and HRMS
Comparison of predicted and observed drug serum levels in pediatric patients using the physiology-based pharmacokinetic model PK-SIM®
Pharmacokinetic/Pharmacodynamic modelling as a tool to define safe dosing regimens for evaluation of dose response of tanogitran (BIBT 986), a novel small molecule parenteral anticoagulant, in a model of endotoxin-induced, tissue factor-triggered coagulation activation in human beings
Penetration kinetics of moxifloxacin after intravenous application in rat and human pancreas
The influence of oral antidiabetics on the uptake of organic cations mediated by organic cation transporter 1
P-Glycoprotein expression in human sigmoidal and rectal biopsies in mesalazine-treated patients with ulcerative colitis
Induction of ATP-binding cassette transporters by efavirenz in vitro
Missense mutations in the multidrug resistance-associated protein 2 (MRP2/ABCC2) and 4 (MRP4/ABCC4)
Functional characterization of cell lines stably transfected with the organic anion transporting polypeptide 4A1
Metabolism of tilidine by human liver microsomes, CYP3A4 and CYP2C19
Bioavailability of voriconazole and its metabolites in human beings
The A270S polymorphism in the human kidney xenobiotic transporter OCT2 exhibits altered function
Altered ATP-binding cassette transporters in human heart failure
Bendamustine phase I metabolism in human beings
Role of CYP2E1 and GSTs in the toxicokinetics of acrylamide and its metabolites in human beings
Impact of CYP3A4, CYP3A5 and ABCB1 genotype and intestinal expression on the pharmacokinetics of budesonide
Measurement of telomerase activity and inhibition in non-small cell lung carcinoma by a modified telomeric repeat amplification protocol
Glutathione S-transferase P1, M1, T1 polymorphisms in patients with colorectal cancer
Multiplex analysis of vitamin D receptor and related metabolism gene polymorphisms
Impact of genetic variants on duodenal expression and on inducibility of ABCC2 and on disposition of talinolol
Impact of CYP2C9 and CYP2C19 polymorphisms on clinical efficacy of CHOP and R-CHOP therapy of follicular lymphoma
Results and indications that breast cancer patients could have a benefit from an anti-IL-6 treatment regiment
Effects of the HIV-1 protease inhibitor tipranavir on platelet aggregation in patients and in vitro and on in vitro thromboxane B2 formation
Glutathione S-transferase polymorphisms and clinical characteristics in patients with colorectal cancer
Differential expression of ppET-1 depending on a +138A insertion in the 5′-UTR of ET-1 gene
Impact of ABCA1 and MPO variants on plasma lipid levels of CAD patients
Influence of telmisartan on nitric oxide-asymmetric dimethylarginine system
Determination of TPMT polymorphisms in different ethnic groups by MALDI-TOF MS
Genetic variation in nucleoside transporters hENT1 and hCNT1 in relation to transporter expression and cytotoxic effects of pyrimidine analogues
Non-synonymous polymorphisms in the human SLCO1B1 gene
NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease
Anti-rhinovirus-specific activity of the α-sympathomimetic oxymetazoline
OATP1B1 polymorphisms and torsemide pharmacokinetics and pharmacodynamics
The incidence of adverse events in first-in-man trials
Experiences from 5-year therapeutic drug monitoring of the human immunodeficiency virus drugs lopinavir, nelfinavir, saquinavir, fosamprenavir, efavirenz, nevirapine, lamivudine, abacavir and zidovudine
Drug information service for physicians
Are you familiar with your medication? Results of a knowledge test on Marcumar®
Therapeutic drug monitoring in psychiatry
Six-year experiences with a drug information service for patients
Saliva-based CYP1A2 phenotyping integrated in a clinical pharmacology curriculum
An algorithm-based drug information tool for drug prescription during pregnancy
Timolol concentration in the human breast milk of a patient with glaucoma
Impact of computerized decision support for drug switching at the interface between primary and tertiary care
Substantial reduction of inappropriate tablet splitting with computerized decision support
Value of defined daily doses for the detection of overdoses in electronic prescriptions
Successful development of a comprehensive database model integrating data of clinical research and the current drug market for computerized decision support
Are pharma pipelines sustainable? A prediction of future pharma output
Changes of the prescription frequency of angiotensin-converting enzyme inhibitors in Saxony over a 2-year interval
Authorization of clinical trials
Clinical pharmacological ward rounds and therapeutic drug monitoring as parts of a drug and therapy information service to detect and prevent severe, rare adverse effects
Systematic review
Cytochrome P450 2D6, 2C9 and 2C19 polymorphisms and the risk of non-chenmotherapy drug-induced agranulocytosis
Suicide attempt of a young adolescent with attention-deficit hyperactivity disorder after change of the methylphenidate product
Drugs causing blood dyscrasias, hepatitis or pancreatitis
Phenprocoumon-associated bleedings
The use of inappropriate medications in the old does not substantially contribute to the occurrence of serious adverse drug reactions leading to hospital admission
Insulin-related hypoglycaemia
Drug–drug interactions leading to hospital admission in the old
VKORC1-, CYP2C9- and CYP3A5-polymorphisms in patients with complicated phenprocoumon therapy
Frequency of serious adverse drug reactions associated with substrates of the polymorphic enzymes CYP2C9, CYP2C19 and CYP2D6