Breast Cancer Research and Treatment. 87(2):197-201, SEP 2004

PMID: 15377844

Issn Print: 0167-6806

Publication Date: 2004/09/01


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Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma

Elisa Sensi;Mariella Tancredi;Paolo Aretini;Giovanna Cipollini;Paola Collecchi;A. Naccarato;Paolo Viacava;Generoso Bevilacqua;Maria Caligo;

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Abstract

SummaryGADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.

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