Breast Cancer Research and Treatment. 87(2):197-201, SEPTEMBER 2004

PMID: 15377844

Issn Print: 0167-6806

Publication Date: September 2004


Share this on facebook   Share this on Twitter   Share this on LinkedIn   Email this article  



Print

Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma

Elisa Sensi;Mariella Tancredi;Paolo Aretini;Giovanna Cipollini;Paola Collecchi;A. Naccarato;Paolo Viacava;Generoso Bevilacqua;Maria Caligo;

+ Author Information


    loading  Checking for direct PDF access through Ovid

Abstract

SummaryGADD45 is a DNA damage responsive gene, induced following BRCA1 expression. Mutations at GADD45 might substitute for p53 alterations in hereditary breast tumours characterized by wild-type p53. We analyzed GADD45 alterations in 59 (15 BRCA-associated) familial breast carcinomas. No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer.

Related Topics

    Related Articles

        loading  Loading Related Articles