1Department of Oncology and Radiotherapy, Polyclinique de Courlancy, Reims, France2Department of Oncology, Groupe Hospitalier Diaconesses-Croix Saint Simon, Paris, France3Department of Oncology, Centre Léon Bérard, Lyon, France4Naxis MAPI Group, Paris, France5AstraZeneca, Rueil Malmaison, France6Department of Oncology and Radiotherapy, Polyclinique de Courlancy, Reims, France; Tel.: +33-3-26-84-02-84; Fax: +33-3-26-84-70-20