Pleomorphic lobular carcinomain situ

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Pleomorphic lobular carcinoma in situ (PLCIS), the cytologic in situ correlate of invasive pleomorphic carcinoma (iPLC), was first recognized as an entity in 2002; however, previous descriptions of in situ lesions in association with iPLC were made in 1992. Recognition of the pleomorphic subtype of lobular carcinoma in situ is important because the combination of cellular features, necrosis and calcification can lead to difficulty in differentiating it from ductal carcinoma in situ and classic lobular carcinoma in situ, lesions for which standard treatment algorithms are supported by data regarding their natural history and risk of subsequent cancer. This article addresses the histological and molecular features that distinguish PLCIS from classic lobular carcinoma in situ and other variants of lobular neoplasia, describes the relationship between PLCIS and iPLC, reviews current challenges in the clinical management of PLCIS and provides a framework for future investigation.

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