Cold Adaptation Modulates Ca2+ Signaling in Brown Preadipocytes

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One-week cold exposure of mice led to a 2-fold increase in the density of α1-adrenoceptors in brown adipose tissue. The density of α1-adrenoceptors returned to normal after adaptation to cold for 2 weeks. The reduced Ca2+ signaling in stem cells of brown fat activated via β-adrenoceptors and cAMP was transformed into the Ca2+-system induced by α1-adrenoceptors and similar to that in mature brown adipocytes.

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