Deltaran Prevents an Adverse Effect of Emotional Stress on the Course of Cerebral Ischemia in Low-Resistant Animals

    loading  Checking for direct PDF access through Ovid

Abstract

Local cerebral blood flow in the left hemisphere decreased most significantly in lowresistant Wistar rats preexposed to emotional stress. Deltaran selectively increased blood flow in the left hemisphere and improved blood supply to neuronal activity unit of the brain in these animals. This drug prevented progressive decrease in local cerebral blood flow in both hemispheres during the acute stage of ischemia. The effect of Deltaran was related to modulation of collateral blood flow and adequate blood supply to neuronal activity unit in the brain tissue. Deltaran decreased the mortality rate (by 62%) and alleviated the symptoms of cerebral ischemia. The positive effect of Deltaran was more pronounced in the left hemisphere.

Related Topics

    loading  Loading Related Articles